Het aanpakken van het hoge genetische risico van diabetes type 2

Een nieuwe studie vindt een sterk verband tussen hoge niveaus van fysieke activiteit en een lager risico op het ontwikkelen van diabetes type 2, zelfs bij personen met een hoge genetische aanleg voor de aandoening. Het onderzoek, waaraan 59.325 UK Biobank-deelnemers deelnamen die gedurende een periode van maximaal zeven jaar werden gevolgd via polsgedragen versnellingsmeters, toonde aan dat een uur of meer matige tot zware fysieke activiteit per dag geassocieerd was met een vermindering van 74% van de ziekte. Diabetes type 2. Vergeleken met minder actieve personen, ongeacht hun genetisch risico.

Kan fysieke activiteit het risico op het ontwikkelen van diabetes type 2 verminderen?

A[{” attribute=””>University of Sydney study suggests high levels of physical activity can significantly lower the risk of developing type 2 diabetes, even for those with a high genetic risk. Over an hour of daily moderate- to vigorous-intensity exercise was linked to a 74% reduction in type 2 diabetes risk, emphasizing the role of physical activity in preventing this condition.

New research has revealed being active could lower the risk of type 2 diabetes, even in people with a high genetic risk of developing the medical condition.

The University of Sydney-led study found higher levels of total physical activity, especially moderate- to vigorous-intensity physical activity, had a strong association with a lower risk of developing type 2 diabetes.

The findings were published on June 5 in the British Journal of Sports Medicine.

The researchers say the study demonstrates higher levels of physical activity should be promoted as a major strategy for type 2 diabetes prevention, which affects millions of Australians.

The study involved 59,325 adults from the UK Biobank, who wore accelerometers (activity trackers worn on their wrists) at the start of the study and were then followed for up to seven years to track health outcomes.

The UK Biobank is a large-scale biomedical database and research resource containing anonymized genetic, lifestyle, and health information from half a million UK participants.

This included genetic markers associated with a higher risk of developing type 2 diabetes. People with a high genetic risk score had 2.4 times the risk of developing type 2 diabetes when compared with those with a low genetic risk score.

The study showed more than an hour of moderate- to vigorous-intensity physical activity per day was associated with a 74 percent lower risk of developing type 2 diabetes when compared with participants who did less than 5 minutes of physical activity,

This was even when other factors, including genetic risk, were accounted for.

Another compelling finding was that participants with a high genetic risk, but who were in the most physically active category, actually had a lower risk of developing type 2 diabetes when compared with those with a low genetic risk but in the least active category.

Senior author Associate Professor Melody Ding from the Charles Perkins Centre and the Faculty of Medicine and Health says although the role of genetics and physical activity in the onset of type 2 diabetes is well established, until now most data was self-reported and there was little evidence whether the genetic risk could be counteracted by physical activity.

“We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can ‘fight off’ much of the excessive risk for type 2 diabetes.”

Associate Professor Ding says moderate-intensity physical activity describes movements that get you sweating and slightly out of breath, such as brisk walking and general gardening.

Examples of vigorous-intensity physical activity include running, aerobic dancing, cycling uphill or at a fast pace, and heavy gardening such as digging – all activities that make you out of breath or cause you to breathe heavily.

Study to help inform public health guidelines

Diabetes is a global public health concern. In 2021, there were 537 million adults living with diabetes worldwide. Almost 1.2 million Australians were recorded as living with type 2 diabetes in 2020.

The findings also hold a strong personal meaning for Associate Professor Ding, whose father was recently diagnosed with type 2 diabetes in his sixties.

“My dad’s side of the family has a history of type 2 diabetes, so the result of the study is extremely heartening for my family and myself. As an already active person, I now have extra motivation to keep this active lifestyle,” says Associate Professor Ding.

“Our hope is that this study will inform public health and clinical guidelines so that it can help chronic disease prevention for health professionals, organisations and the public.”

“I am so delighted to share our research results with a broad audience to let people know that physical activity is health-enhancing, especially for people with high genetic risk. If you have a family history of type 2 diabetes, or even if you don’t, today is the day to start being physically active,” says PhD candidate Mengyun (Susan) Luo, who led the study.

Reference: “Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study” by Mengyun Luo, Chenhao Yu, Borja Del Pozo Cruz, Liangkai Chen and Ding Ding, 5 June 2023, British Journal of Sports Medicine.
DOI: 10.1136/bjsports-2022-106653

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